Chemotherapy vs. Immunotherapy in combating nCOVID19: An update

Area of Science:

• Infectious Diseases
• Immunology
• Pharmacology

Background:

• The global nCOVID-19 pandemic, caused by SARS-CoV-2, has led to significant mortality and multi-organ symptoms.
• Viral-host interactions trigger a 'cytokine storm,' causing severe immunopathological consequences and death.

Purpose of the Study:

• To provide a comprehensive overview of chemotherapeutic and immunotherapeutic strategies for nCOVID-19 management.
• To explore potential curative approaches for the SARS-CoV-2 infection.

Main Methods:

• Review of current chemotherapeutic approaches targeting viral entry, proliferation, and inflammation.
• Analysis of immunotherapeutic strategies aimed at modulating host immune responses and inflammatory cascades.

Main Results:

• Chemotherapy aims to inhibit viral activity and reduce inflammation.
• Immunotherapy seeks to regulate host immunity for viral prophylaxis and restore immune balance.

Conclusions:

• Combinatorial therapy integrating chemotherapeutics and immunotherapeutics shows promise.
• Vaccine development alongside these therapies could be key to eradicating the nCOVID-19 crisis.