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Updated: Nov 4, 2025
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
11.4K
Blastoid mantle cell lymphoma: cutaneous infiltration.
Mariana Righetto de Ré1, Flávia de Oliveira Valentim1, Mariangela Esther Alencar Marques1
1Department of Dermatology, Faculty of Medicine, Universidade Estadual Paulista, São Paulo, SP, Brazil.
Anais Brasileiros De Dermatologia
|May 22, 2021
Summary
Mantle cell lymphoma, an aggressive B-cell cancer, rarely involves the skin. This case highlights secondary cutaneous infiltration of blastoid lymphoma during chemotherapy, indicating disease dissemination.
Area of Science:
- Hematology
- Oncology
- Dermatopathology
Background:
- Mantle cell lymphoma (MCL) is an aggressive B-cell, non-Hodgkin's lymphoma.
- It typically originates in lymph nodes or extranodally, with a poor prognosis.
- Skin involvement in MCL is uncommon and usually signifies advanced disease.
Observation:
- A 69-year-old female patient with a prior MCL diagnosis presented with new skin lesions.
- The lesions appeared as infiltrated plaques, nodules, and tumors on the trunk and thigh.
- These symptoms emerged during her second chemotherapy regimen.
Findings:
- Histopathology and immunohistochemistry confirmed cutaneous infiltration by blastoid lymphoma.
- The findings indicated secondary spread of the neoplasm to the skin.
Implications:
- This case underscores the importance of recognizing rare skin manifestations in MCL.
- Cutaneous involvement can serve as a marker for disseminated lymphoma.
- Further investigation into the clinical significance of secondary skin infiltration in MCL is warranted.
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