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Cell-mediated Immune Responses

Cell-mediated Immune Responses

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Updated: Nov 4, 2025

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Published on: November 10, 2023

Innate immunity in lung transplantation.

Hailey M Shepherd¹, Jason M Gauthier¹, Wenjun Li¹

¹Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation

|May 22, 2021

Summary

Innate immune responses after lung transplantation can cause primary graft dysfunction and late graft failure. Understanding these mechanisms may lead to new lung-specific therapies to improve transplant outcomes.

Keywords:

cell death damage-associated molecular patterns graft rejection innate immunity lung transplantation

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Last Updated: Nov 4, 2025

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Published on: November 10, 2023

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Author Spotlight: Advancing Lung Transplant Immunology Through Intravital Imaging

Author Spotlight: Advancing Lung Transplant Immunology Through Intravital Imaging

Published on: April 19, 2024

Area of Science:

Immunology
Transplantation Biology
Pulmonary Medicine

Background:

Innate immune responses post-pulmonary transplantation are implicated in primary graft dysfunction (PGD) and long-term graft failure.
Animal models have revealed key mechanisms driving innate immune responses in the context of lung transplantation.

Purpose of the Study:

To discuss the inflammatory cell death pathways, triggers of sterile and infectious inflammation, and signaling cascades involved in early lung injury after transplantation.
To identify potential targets for lung-specific therapies aimed at mitigating innate immune responses and enhancing graft survival.

Main Methods:

Review of recent studies and animal models elucidating innate immune mechanisms in lung transplantation.
Discussion of inflammatory cell death pathways, inflammation triggers (sterile and infectious), and signaling cascades mediating lung injury.

Main Results:

Elucidation of critical mechanisms governing innate immune responses in early lung allografts.
Identification of pathways contributing to primary graft dysfunction and predisposition to late graft failure.

Conclusions:

Understanding innate immunity is crucial for addressing complications following lung transplantation.
Targeting specific innate immune pathways offers potential for developing novel lung-specific therapies to improve transplant outcomes.