Related Experiment Video

Updated: Nov 4, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
08:49

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

9.3K

cGAS-STING Pathway Activation in cDCs Underlies TIM3 Blockade Efficacy

    Cancer Discovery
    |May 22, 2021
    PubMed

    Abstract:

    TIM3-blocking antibodies promoted extracellular DNA uptake by conventional dendritic cells (cDC).

    More Related Videos

    Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
    09:08

    Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

    Published on: June 2, 2021

    2.0K
    Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
    10:13

    Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

    Published on: May 6, 2019

    9.2K

    Related Experiment Videos

    Last Updated: Nov 4, 2025

    Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
    08:49

    Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

    Published on: January 22, 2019

    9.3K
    Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
    09:08

    Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

    Published on: June 2, 2021

    2.0K
    Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
    10:13

    Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

    Published on: May 6, 2019

    9.2K

    Related Concept Videos

    GPCRs Regulate Adenylyl Cylase Activity01:09

    GPCRs Regulate Adenylyl Cylase Activity

    6.2K
    Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
    6.2K

    Articles linked to this work by shared authors, journal, and citation graph.

    Q&A: Eileen O'Reilly on Pancreatic Cancer.

    Cancer discovery·2026

    Cellular and molecular mechanisms determining allogeneic CAR T cell rejection and expansion.

    Cancer discovery·2026

    Microplastics and Cancer: Still Searching for Causation.

    Cancer discovery·2026

    Targeting RAS for Pancreatic Cancer Interception.

    Cancer discovery·2026

    The liver niche accelerates, while the lung niche restrains secondary spread of breast cancer.

    Cancer discovery·2026

    Dual Functions of B7-H3-MAPK Signaling Orchestrate Tumor Immunosuppression via Regulating the Plasticity of Myeloid-derived Suppressor Cells and Fibroblasts.

    Cancer discovery·2026

    Spirooxindole 5-(Trifluoromethyl)benzothiazole Hybrids: Synthesis, Crystal Structure, and Antioxidant Activity.

    Archiv der Pharmazie·2026

    In Vitro Hepatotoxicity and Cytochrome P450 (CYP) Inhibitory Potential of a Selected Commercial Herbal Supplement Juice.

    Journal of applied toxicology : JAT·2026

    Synthesis, Tautomeric Behavior, and Biological Activity of 6-Unsubstituted 2-Aryl-1,4-dihydropyrimidines and 4-Unsubstituted 2-Aryl-1,6-dihydropyrimidines.

    Chemical & pharmaceutical bulletin·2026

    Cytochrome P450 enzymes in the biosynthesis of bioactive diterpenoids from traditional chinese medicinal plants.

    Fitoterapia·2026

    Podocarpane diterpenoids with various subtypes from Strophioblachia glandulosa Pax var. cordifolia combined with fluconazole activation of the Hog1 pathway demonstrating antifungal activity.

    Bioorganic chemistry·2026

    Diterpenoids from the leaves of Thuja orientalis L. and their inhibitory effects on PTP1B and α-glucosidase.

    Bioorganic chemistry·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies
    Jove
    Visualize
    Contact Us