Two new dipimprinine alkaloids from soil-derived Streptomyces sp. 44414B
Manli Liu1, Zhongyi Wan1, Sumei Yang2
1Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan, China.
The Journal of Antibiotics
|May 22, 2021
Abstract:
Two new dipimprinine alkaloids dipimprinine E (1) and dipimprinine F (2) were isolated from Streptomyces sp. 44414B. The structure was elucidated by extensive spectroscopic analysis, including ESI-MS, HR-MS, and 1D and 2D NMR experiments. Dipimprinines F (2) showed cytotoxic activities against three tumor cell lines, including A-875, Hep G2, and H-460, with IC50 values of 26.4, 0.5, and 9.0 μg ml-1, respectively.


