PET/CT using ⁶⁸ Ga-PSMA-617 versus ¹⁸ F-fluorodeoxyglucose to differentiate low- and high-grade gliomas

To compare and characterize metabolic features of high- and low-grade glioma tumors using ⁶⁸ Ga-PSMA-617 and ¹⁸ F-FDG positron emission tomography/computed tomography (PET/CT).

Thirty patients who underwent both ⁶⁸ Ga-PSMA-617 and ¹⁸ F-FDG PET/CT over 2 consecutive days and then underwent surgical treatment were retrospectively identified. All tumors were diagnosed histologically. This report includes 16 high-grade glioma (HGG) and 14 low-grade glioma (LGG) tumors. Standard uptake value (SUV) and target to nontarget (T/NT) were quantitatively investigated through the entire tumor region. Statistical analyses were performed using area under the curve (AUC) and comparison of two means.

SUV_max and SUV_mean were the most effective (AUC, 0.96 and 0.94 for PSMA PET; AUC, 0.79 and 0.74 for FDG PET, respectively) for differentiating HGGs from LGGs. These methods distinguished between HGG and LGG effectively (PSMA PET: SUV_max , 5.766 ± 3.945 vs. 0.7364 ± 0.5295, p < 0.0001; SUV_mean , 1.666 ± 1.680 and 0.1514 ± 0.1534, p < 0.0001, respectively) (FDG PET: SUV_max , 11.67 ± 3.639 and 9.118 ± 6.612; SUV_mean , 5.648 ± 2.114 and 4.435 ± 2.872; p = 0.0083, 0.0262, respectively). The Youden index for SUV_max and SUV_mean of ⁶⁸ Ga-PSMA-617 and ¹⁸ F-FDG were 0.82 and 0.79 and 0.54 and 0.61, separately. T/NT_max was helpful for visual inspection of ⁶⁸ Ga-PSMA-617-PET images (T/NT_max : 1.291 ± 0.9553 in grade II, 5.25 ± 2.435 in grade III, and 13.61 ± 13.84 in grade IV). T/NT_max differed significantly between LGG and HGG and between subtypes of LGG.

PET/CT with ⁶⁸ Ga-PSMA-617 and ¹⁸ F-FDG may help distinguish between HGG and LGG, and ⁶⁸ Ga-PSMA-617 PET/CT is superior to¹⁸ F-FDG in differentiating HGG and LGG.