Related Experiment Video
Updated: Nov 4, 2025

Prediction of Red Blood Cell Antibody Significance Using the Monocyte-Macrophage Assay
Published on: February 7, 2025
Non-ABO red cell antibodies and risk of COVID-19
Joel G Ray1, Michael Colacci2, Michael J Schull3
1Department of Medicine, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, M5B 1W8 Canada; ICES, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 Canada.
Abstract:
It is not known whether non-ABO antibodies confer any protective effect against SARS-CoV-2 infection or COVID-19 severe illness alone or in conjunction with O blood group. This cohort study included 413 576 persons in Ontario, Canada with known ABO blood group and non-ABO antibody screen status, who subsequently underwent SARS-CoV-2 viral RNA polymerase chain reaction testing between January and November 2020. The risk of SARS-CoV-2 infection or COVID-19 severe illness was not associated with the presence of non-ABO antibodies, even among persons with O blood group.
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