Related Experiment Video
Updated: Nov 4, 2025
Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
Published on: October 28, 2021
Advances in targeted therapy for osteosarcoma based on molecular classification
Yingqian Chen1, Runzhi Liu1, Wei Wang1
1Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Abstract:
Osteosarcoma, a highly malignant tumor, is characterized by widespread and recurrent chromosomal and genetic abnormalities. In recent years, a number of elaborated sequencing analyses have made it possible to cluster the osteosarcoma based on the identification of candidate driver genes and develop targeted therapy. Here, we reviewed recent next-generation genome sequencing studies and advances in targeted therapies for osteosarcoma based on molecular classification. First, we stratified osteosarcomas into ten molecular subtypes based on genetic changes. And we analyzed potential targeted therapies for osteosarcoma based on the identified molecular subtypes. Finally, the development of targeted therapies for osteosarcoma investigated in clinical trials were further summarized and discussed. Therefore, we indicated the importance of molecular classification on the targeted therapy for osteosarcoma. And the stratification of patients based on the genetic characteristics of osteosarcoma will help to obtain a better therapeutic response to targeted therapies, bringing us closer to the era of personalized medicine.
Insights
Molecular classification of osteosarcoma, a rare bone cancer, aids in developing targeted therapies. Stratifying patients by genetic profiles improves treatment response for personalized medicine.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Osteosarcoma is a malignant bone tumor with complex genetic abnormalities.
- Recent advances in genome sequencing enable molecular classification of osteosarcoma.
- Identifying driver genes is crucial for developing targeted therapeutic strategies.
Purpose of the Study:
- To review next-generation sequencing studies and targeted therapies for osteosarcoma.
- To stratify osteosarcomas into molecular subtypes based on genetic alterations.
- To analyze potential targeted therapies tailored to specific molecular subtypes.
Main Methods:
- Comprehensive review of recent next-generation genome sequencing studies.
- Molecular classification of osteosarcoma into ten distinct subtypes.
- Analysis of targeted therapy options for each identified molecular subtype.
Main Results:
- Osteosarcomas were successfully stratified into ten molecular subtypes.
- Specific targeted therapies were identified for each subtype.
- Clinical trial data on targeted therapies for osteosarcoma were summarized.
Conclusions:
- Molecular classification is essential for effective targeted therapy in osteosarcoma.
- Patient stratification based on genetic characteristics enhances therapeutic response.
- This approach advances personalized medicine for osteosarcoma patients.
Related Concept Videos
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
03:03mTOR Signaling and Cancer Progression
The mTOR pathway or the...
02:50Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
02:56Treatment Resistant Cancers