Detection of deep myometrial invasion in endometrial cancer MR imaging based on multi-feature fusion and...

The depth of myometrial invasion affects the treatment and prognosis of patients with endometrial cancer (EC), conventionally evaluated using MR imaging (MRI). However, only a few computer-aided diagnosis methods have been reported for identifying deep myometrial invasion (DMI) using MRI. Moreover, these existing methods exhibit relatively unsatisfactory sensitivity and specificity. This study proposes a novel computerized method to facilitate the accurate detection of DMI on MRI. This method requires only the corpus uteri region provided by humans or computers instead of the tumor region. We also propose a geometric feature called LS to describe the irregularity of the tissue structure inside the corpus uteri triggered by EC, which has not been leveraged for the DMI prediction model in other studies. Texture features are extracted and then automatically selected by recursive feature elimination. Utilizing a feature fusion strategy of strong and weak features devised in this study, multiple probabilistic support vector machines incorporate LS and texture features, which are then merged to form the ensemble model EPSVM. The model performance is evaluated via leave-one-out cross-validation. We make the following comparisons, EPSVM versus the commonly used classifiers such as random forest, logistic regression, and naive Bayes; EPSVM versus the models using LS or texture features alone. The results show that EPSVM attains an accuracy, sensitivity, specificity, and F1 score of 93.7%, 94.7%, 93.3%, and 87.8%, all of which are higher than those of the commonly used classifiers and the models using LS or texture features alone. Compared with the methods in existing studies, EPSVM exhibits high performance in terms of both sensitivity and specificity. Moreover, LS can achieve an accuracy, sensitivity, and specificity of 89.9%, 89.5%, and 90.0%. Thus, the devised geometric feature LS is significant for DMI detection. The fusion of LS and texture features in the proposed EPSVM can provide more reliable prediction. The computer-aided classification based on the proposed method can assist radiologists in accurately identifying DMI on MRI.