Related Experiment Video
Updated: Nov 4, 2025
Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
Published on: March 7, 2022
Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review
Fuwen Huang1, Jingting Mai2, Jingwei Chen2
1The Fifth People's Hospital of Zhuhai, Zhuhai City, Guangdong Province, China.
Insights
Non-coding RNAs (ncRNAs) regulate autophagy in myocardial ischemia-reperfusion (I/R) injury, a key factor in heart attack damage. Understanding these ncRNAs offers potential new therapies for heart attack and related cardiovascular diseases.
Area of Science:
- Cardiovascular Biology
- Molecular Medicine
- Genetics
Background:
- Myocardial infarction (heart attack) remains a leading cause of death globally.
- While reperfusion therapies like PCI significantly reduce mortality, they can paradoxically worsen heart damage through ischemia-reperfusion (I/R) injury.
- Non-coding RNAs (ncRNAs), including microRNAs, long noncoding RNAs, and circular RNAs, are implicated in the progression of myocardial I/R injury.
Purpose of the Study:
- To review the biogenesis and functions of ncRNAs.
- To summarize the roles and molecular mechanisms of ncRNAs in regulating autophagy during myocardial I/R injury.
- To provide a foundation for developing novel therapeutic strategies for myocardial I/R injury and other cardiovascular diseases.
Main Methods:
- Literature review focusing on ncRNAs, autophagy, and myocardial I/R injury.
- Analysis of molecular mechanisms linking ncRNAs to autophagy in the context of I/R injury.
- Synthesis of current understanding of ncRNA regulation of autophagy in cardiovascular pathophysiology.
Main Results:
- ncRNAs play a significant role in the pathological processes of myocardial I/R injury.
- Autophagy is a critical cellular process modulated by ncRNAs during myocardial I/R and hypoxia-reoxygenation (H/R) injury.
- Specific ncRNAs influence cardiomyocyte homeostasis and survival following ischemic events.
Conclusions:
- ncRNAs are key regulators of autophagy in myocardial I/R injury.
- Targeting ncRNA-autophagy pathways presents a promising therapeutic avenue for myocardial I/R injury.
- Further research into ncRNAs can advance treatments for cardiovascular diseases.
Abstract:
The myocardial infarction is the main cause of morbidity and mortality in cardiovascular diseases around the world. Although the timely and complete reperfusion via Percutaneous Coronary Intervention (PCI) or thrombolysis have distinctly decreased the mortality of myocardial infarction, reperfusion itself may lead to supererogatory irreversible myocardial injury and heart function disorders, namely ischemia-reperfusion (I/R) injury. Extensive studies have indicated that non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), play important roles in the progress of myocardial I/R injury, which is closely correlative with cardiomyocytes autophagy. Moreover, autophagy plays an important role in maintaining homeostasis and protecting cells in the myocardial ischemia reperfusion and cardiomyocyte hypoxia-reoxygenation (H/R) progress. In this review, we first introduced the biogenesis and functions of ncRNAs, and subsequently summarized the roles and relevant molecular mechanisms of ncRNAs regulating autophagy in myocardial I/R injury. We hope that this review in addition to develop a better understanding of the physiological and pathological roles of ncRNAs, can also lay a foundation for the therapies of myocardial I/R injury, and even for other related cardiovascular diseases.
