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Published on: February 19, 2016
Non-spherical micro- and nanoparticles for drug delivery: Progress over 15 years
Neha Kapate1, John R Clegg2, Samir Mitragotri2
1Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
Particle shape significantly impacts drug delivery outcomes. Understanding how non-spherical drug carriers interact with biological systems is crucial for developing effective disease treatments.
Area of Science:
- Nanotechnology and Materials Science
- Biomedical Engineering
- Pharmacology
Background:
- Particulate drug carriers' biological outcomes are critically influenced by their shape.
- The field is transitioning from basic research to practical applications in disease treatment.
Purpose of the Study:
- To review the influence of particle shape on biological interactions and therapeutic efficacy.
- To highlight key fabrication, characterization, and application-related challenges and future directions.
Main Methods:
- Comprehensive literature review focusing on particle shape in drug delivery.
- Analysis of fabrication and characterization techniques for non-spherical particles.
- Discussion of biological interactions: cellular uptake, vascular transport, targeting, and immunomodulation.
Main Results:
- Particle shape dictates cellular interactions, vascular circulation, biodistribution, and immune response.
- Current research emphasizes the potential of non-spherical carriers to overcome biological barriers.
Conclusions:
- Further research is needed on characterization, quality control, and appropriate model systems for translating findings.
- Designing advanced non-spherical drug carriers is essential for enhancing therapeutic efficacy.
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