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Related Concept Videos

Brain Imaging01:14

Brain Imaging

446
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
446

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Intracranial brain stimulation modulates fMRI-based network switching.

Mangor Pedersen1, Andrew Zalesky2

  • 1Department of Psychology and Neuroscience, Auckland University of Technology (AUT), Auckland, New Zealand.

Neurobiology of Disease
|May 23, 2021
PubMed
Summary

Electrical stimulation (es-fMRI) reduced brain network switching in epilepsy patients. This suggests neuronal perturbations modulate brain networks, potentially informing epilepsy treatment efficacy.

Keywords:
EpilepsyIntracranial brain stimulationMultilayer networksNetwork switchingfMRI

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Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Computational Neuroscience

Background:

  • The relationship between functional MRI (fMRI) signals and direct neuronal activity is not fully understood.
  • Epilepsy is associated with altered brain network dynamics, including an increased rate of network switching.

Purpose of the Study:

  • To investigate if intracranial brain stimulation alters dynamic brain network switching.
  • To determine if brain network switching is reduced following intracranial stimulation in epilepsy patients.

Main Methods:

  • Simultaneous electrical stimulation (es-fMRI) and intracranial recordings were used in 26 epilepsy patients.
  • Multilayer modularity analysis and time-resolved connectivity quantified network switching rates.
  • Brain network dynamics were analyzed in response to intracranial brain stimulation.

Main Results:

  • Intracranial stimulation decreased network switching and synchrony, particularly in cortical networks near electrode targets.
  • A more consistent pattern of network switching emerged after initial stimulation.
  • Neuronal perturbation was observed to modulate large-scale brain networks.

Conclusions:

  • Intracranial brain stimulation can modulate large-scale brain network dynamics.
  • Multilayer network modeling may help predict the clinical effectiveness of brain stimulation for epilepsy.