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Inhalation toxicity of methyl difluoromalonyl fluoride in rats
G L Kennedy1, B A Burgess, H C Chen
1Central Research and Development Department, E. I. du Pont de Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine, Newark, Delaware 19714.
Abstract:
Methyl 2,2-difluoromalonyl fluoride (MMF) is highly toxic by inhalation producing mortality in rats exposed for 4 hours to 0.55 mg/L. Repeated inhalation exposures of rats to 0.009 mg/L produced irritation but no other signs of a toxic response. Mortality was encountered following repeated exposures to 0.066 mg/L.
Insights
Methyl 2,2-difluoromalonyl fluoride (MMF) is highly toxic via inhalation, causing rat mortality at 0.55 mg/L. Lower repeated exposures caused irritation, but higher doses led to fatalities.
Area of Science:
- Toxicology
- Inhalation Toxicology
Background:
- Methyl 2,2-difluoromalonyl fluoride (MMF) is a chemical compound.
- Understanding the toxicological profile of MMF is crucial for occupational safety.
Purpose of the Study:
- To determine the acute and repeated inhalation toxicity of Methyl 2,2-difluoromalonyl fluoride (MMF) in rats.
Main Methods:
- Rats were exposed to varying concentrations of MMF via inhalation for 4-hour acute or repeated exposure studies.
- Mortality and signs of toxic response were recorded.
Main Results:
- Acute inhalation exposure to 0.55 mg/L of MMF for 4 hours resulted in mortality in rats.
- Repeated inhalation exposure to 0.009 mg/L caused irritation but no other toxic effects.
- Repeated inhalation exposure to 0.066 mg/L led to mortality.
Conclusions:
- Methyl 2,2-difluoromalonyl fluoride (MMF) exhibits significant inhalation toxicity.
- The compound can cause mortality at relatively low concentrations following repeated exposures.