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Lanadelumab Efficacy, Safety, and Injection Interval Extension in HAE: A Real-Life Study
Thomas Buttgereit1, Carolina Vera1, Karsten Weller1
1Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Lanadelumab effectively manages hereditary angioedema by improving disease control and quality of life. Gradual extension of injection intervals minimizes treatment burden without compromising efficacy in real-world settings.
Area of Science:
- Immunology
- Pharmacology
Background:
- Lanadelumab has been available in Germany since February 2019 for hereditary angioedema prophylaxis.
- Real-world data on lanadelumab's effectiveness and treatment adaptation is valuable.
Purpose of the Study:
- To investigate the real-life treatment outcomes of lanadelumab.
- To gain practical experience in adapting lanadelumab therapy to individual patient needs.
Main Methods:
- 34 patients with hereditary angioedema or acquired C1-inhibitor deficiency were included.
- Treatment was switched to lanadelumab, or existing treatment continued.
- Patients were monitored using the Angioedema Control Test and Angioedema Quality of Life Questionnaire, with gradual dose interval increases upon symptom resolution.
Main Results:
- Angioedema Control Test scores improved significantly, indicating well-controlled disease for all patients.
- Most patients reported only a slight reduction in quality of life.
- Many patients achieved symptom freedom and extended their injection intervals, while some required dose adjustments.
Conclusions:
- Gradual extension of lanadelumab injection intervals can minimize treatment burden.
- Therapeutic efficacy is maintained even with extended dosing intervals.
