[Principle methods of determining plasma 3-methoxy-4-hydroxyphenyl glycol]

The dosage of plasma 3-methoxy-4-hydroxyphényl glycol (MHPG) presents a great interest, specially in psychiatry. Several methods are described: gas chromatography, with or without mass spectrometry, high performance liquid chromatography with some internal standard problems and with different modes of extractions and radioimmunoassay. Every method presents advantages but also inconveniences which are discussed.