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Related Experiment Video

Updated: Nov 4, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Atrial fibrillation and kidney function: a bidirectional Mendelian randomization study.

Sehoon Park1,2, Soojin Lee3, Yaerim Kim4

  • 1Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.

European Heart Journal
|May 23, 2021
PubMed
Summary

Atrial fibrillation (AF) causally increases the risk of impaired kidney function, including chronic kidney disease. However, this study found no evidence that kidney function affects the risk of developing AF.

Keywords:
Atrial fibrillationChronic kidney diseaseEstimated glomerular filtration rateMendelian randomization

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Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Genetics

Background:

  • Atrial fibrillation (AF) and chronic kidney disease (CKD) are prevalent conditions with shared risk factors.
  • The etiological relationship between AF and kidney function remains incompletely understood.

Purpose of the Study:

  • To investigate the causal relationship between atrial fibrillation and kidney function using a bidirectional Mendelian randomization approach.

Main Methods:

  • Bidirectional summary-level Mendelian randomization (MR) analysis utilized large genome-wide association study data for AF (N=588,190) and estimated glomerular filtration rate (eGFR) (N=765,348).
  • Inverse variance weighted (IVW) method was the primary MR analysis technique.
  • Replication was performed using allele score-based MR with individual-level data from the UK Biobank (N=337,138).

Main Results:

  • A genetic predisposition to AF was significantly associated with decreased eGFR (beta -0.003, P < 0.001) and increased risk of CKD (beta 0.059, P < 0.001).
  • These findings were consistent across MR sensitivity analyses and in replication using allele score-based MR (beta -0.079, P < 0.001).
  • Conversely, genetically predicted eGFR did not show a significant causal association with the risk of AF (beta -0.366, P = 0.183).

Conclusions:

  • Atrial fibrillation is a causal risk factor for kidney function impairment.
  • No significant causal effect of kidney function on the risk of atrial fibrillation was identified in this study.