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Vitamin D and its correlation with blood lipids and intima-media thickness in term infants

Ana Daniela Ortega-Ramírez1, Alejandro Cabrera-Macedo1, Mario Del Toro-Equihua1

  • 1Nutrition Laboratory. Facultad de Medicina. Universidad de Colima.

Nutricion Hospitalaria
|May 24, 2021
PubMed

Insights

In infants aged 3-9 months, vitamin D (25(OH)D) levels correlated positively with total and non-HDL cholesterol in those receiving breastmilk substitutes. Low vitamin D deficiency was observed, with no link to artery thickness.

Area of Science:

  • Pediatric endocrinology
  • Nutritional science
  • Cardiovascular health

Background:

  • Existing research links low vitamin D (25(OH)D) to blood lipids in older populations.
  • The relationship between vitamin D, blood lipids, and arterial thickness in infants is not well-established.
  • Carotid and aortic intima-media thickness associations with vitamin D are controversial.

Purpose of the Study:

  • To investigate the correlation between 25(OH)D levels and blood lipids (total cholesterol, HDL, non-HDL) in infants aged 3-9 months.
  • To examine the relationship between 25(OH)D levels and carotid and aortic intima-media thickness in this age group.
  • To assess the prevalence of vitamin D deficiency and insufficiency in healthy term infants.

Main Methods:

  • Cross-sectional study of 109 healthy term infants (3-9 months old).
  • Measured serum 25(OH)D, total cholesterol, HDL-cholesterol, non-HDL-cholesterol.
  • Assessed aortic and carotid intima-media thickness; recorded feeding method, vitamin D supplementation, and sun exposure.

Main Results:

  • Vitamin D deficiency (2.8%) and insufficiency (10.1%) were low.
  • Inadequate vitamin D levels were associated with younger age (<6 months) and less sun exposure.
  • Positive correlation between 25(OH)D and non-HDL-cholesterol in breastmilk substitute consumers and partially breastfed infants.
  • Positive correlation between 25(OH)D and total cholesterol in breastmilk substitute consumers.
  • No significant correlation found between vitamin D and aortic or carotid intima-media thickness.

Conclusions:

  • A positive correlation exists between 25(OH)D levels and total and non-HDL-cholesterol in infants consuming breastmilk substitutes.
  • The prevalence of vitamin D deficiency and insufficiency is low in the studied infant population.
  • Vitamin D levels were not correlated with aortic or carotid intima-media thickness in 3-9 month old infants.
Abstract

Keywords:
Vitamina D. Colesterol. Íntima-media. Tipo de alimentación.

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