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Increased local IgA production in chronic obstructive pulmonary disease
T S Mair1, C R Stokes, F J Bourne
1Department of Veterinary Medicine, University of Bristol, School of Veterinary Science, Langford, Avon.
Equine Veterinary Journal
|May 1, 1988
Summary
This study found that horses with chronic obstructive pulmonary disease (COPD) show increased local production of immunoglobulin A (IgA) in their respiratory tracts, suggesting immune system involvement in the disease.
Area of Science:
- Veterinary Immunology
- Respiratory Medicine
- Equine Health
Background:
- Chronic Obstructive Pulmonary Disease (COPD) is a significant respiratory condition in horses.
- The role of the local respiratory mucosal immune system in COPD pathogenesis is not fully understood.
Purpose of the Study:
- To investigate the local production of immunoglobulins in the lower respiratory tract of horses with COPD.
- To compare immunoglobulin levels in serum and tracheal lavage fluid between horses with and without COPD.
Main Methods:
- Serum and tracheal lavage fluid were collected from 50 horses with COPD and 40 control horses.
- Immunoglobulin (Ig) and albumin concentrations were measured.
- Immunoglobulin:albumin ratios were calculated to assess local immunoglobulin production.
Main Results:
- Immunoglobulin:albumin ratios were higher in lavage fluid than in serum for both groups, indicating local immunoglobulin production in the respiratory tract.
- Diseased horses had a significantly higher IgA:albumin ratio in lavage fluid compared to controls, suggesting increased local IgA production.
- No significant differences were found in IgG:albumin or IgM:albumin ratios between the groups.
Conclusions:
- The findings indicate active involvement of the respiratory mucosal immune system in equine COPD.
- Increased local production of IgA is a feature of COPD in horses.
- Further research into the specific roles of IgA in COPD pathogenesis is warranted.