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Updated: Aug 16, 2026

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
Published on: November 14, 2016
N,N-Dimethylglycine in patients with progressive multiple sclerosis: result of a pilot double-blind, placebo,
Thomas Wolfsegger1, Klaus Böck2, Wolfgang Schimetta3
1Department of Neurology 1, Kepler University Hospital, Neuromed Campus, Wagner-Jauregg-Weg 15, 4020, Linz, Austria. thomas.wolfsegger@kepleruniklinikum.at.
Abstract:
Oral administration of N,N-Dimethylglycine (DMG), a tertiary amino acid, presumably enhances oxygen utilization by tissue and complex with free radicals. Beneficial effects are improved endurance performance and reduction fatigue in humans and animals. This pilot study reports the results over a one-year double-blind, placebo-controlled trial of DMG in 30 randomized patients with progressive multiple sclerosis. No treatment effects were found between the placebo group and the DMG group for disability, fatigue, cognitive, or gait parameters.
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