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IL32: The multifaceted and unconventional cytokine
Anuradha Gautam1, Bhaswati Pandit1
1National Institute of Biomedical Genomics (NIBMG), Kalyani, West Bengal 741251, India.
Human Immunology
|May 24, 2021
Summary
Interleukin 32 (IL32) is an intracellular cytokine influencing cell death, inflammation, and pathogen response. This review details IL32
Area of Science:
- Immunology
- Molecular Biology
- Genetics
Background:
- Interleukin 32 (IL32) is a unique intracellular cytokine with diverse roles in cellular functions.
- It influences cell death, survival, inflammation, and immune responses against various pathogens.
- IL32 is implicated in inflammatory cancers and chronic diseases like rheumatoid arthritis and COPD.
Purpose of the Study:
- To review the identification, characterization, structure, and function of IL32.
- To explore the diverse functions of IL32 isoforms.
- To highlight the role of IL32 in diseases, particularly mycobacterial infections, and discuss genetic variants.
Main Methods:
- Literature review of studies on IL32.
- Analysis of IL32 gene and protein structure and function.
- Summary of research on IL32's role in various diseases and genetic variations.
Main Results:
- IL32 exhibits multiple transcripts and biologically active isoforms.
- It modulates immune responses and is involved in metabolic processes and infections.
- Genetic variants in the IL32 gene and promoter region are associated with disease phenotypes.
Conclusions:
- IL32 is a significant cytokine with broad implications in health and disease.
- Understanding IL32's function and genetic variations is crucial for disease management.
- Further research into IL32 pathways may offer therapeutic targets for inflammatory and infectious diseases.
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