Related Experiment Video

Updated: Nov 4, 2025

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure
04:20

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure

Published on: October 1, 2019

6.0K

Cardiopulmonary exercise testing in patients with Cardiac Amyloidosis

Divaya Bhutani1, Samuel Pan2, Farhana Latif3

  • 1Division of Hematology and Oncology, Department of Medicine Columbia University Irving Medical Center.

Clinical Lymphoma, Myeloma & Leukemia
|May 24, 2021
PubMed

Insights

Cardiopulmonary exercise testing reveals reduced functional capacity in cardiac amyloidosis patients. Findings suggest light chain toxicity contributes to cardiac dysfunction in AL amyloidosis.

Area of Science:

  • Cardiology
  • Cardiovascular Research
  • Amyloidosis Research

Background:

  • Cardiac involvement is frequent in AL and ATTR amyloidosis.
  • Cardiopulmonary exercise testing (CPET) is the standard for assessing functional capacity.

Purpose of the Study:

  • To evaluate CPET measurements in cardiac amyloidosis patients.
  • To correlate CPET data with existing amyloidosis staging criteria.

Main Methods:

  • Studied 41 patients with cardiac amyloidosis (AL and ATTR types).
  • Analyzed cardiopulmonary exercise testing (CPET) parameters.
  • Correlated CPET results with cardiac biomarker levels.

Main Results:

  • Percent predicted peak VO2 was significantly reduced in both AL and ATTR cardiac amyloidosis.
  • Reduced peak VO2 correlated with cardiac biomarker abnormalities.
  • The association between peak VO2 and biomarkers was stronger in AL amyloidosis, suggesting light chain toxicity.

Conclusions:

  • Findings provide further evidence for light chain toxicity in AL amyloidosis.
  • CPET is a valuable tool for assessing functional capacity in cardiac amyloidosis.
Abstract

Keywords:
Cardiac amyloidosisCardiopulmonary testing

More Related Videos

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine12:37

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine

Published on: February 9, 2016

13.6K
Author Spotlight: Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System02:47

Author Spotlight: Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System

Published on: May 12, 2023

1.6K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
114
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
113
Exercise Stress Test01:26

Exercise Stress Test

Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
631
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
96
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
149
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
62