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Evading the Immune System: Immune Modulation and Immune Matching in Cell Replacement Therapies for Parkinson's

Asuka Morizane1,2, Jun Takahashi2

  • 1Department of Regenerative Medicine, Center for Clinical Research and Innovation, Kobe City Medical Center General Hospital, Hyogo, Japan.

Journal of Parkinson'S Disease
|May 24, 2021
PubMed

Stem cell-based therapies for Parkinson's disease are now being applied clinically. Notably, studies have shown that controlling the graft-induced immune response improves the results. In this mini-review, we concisely summarize current approaches used for this control. We focus on four modes of stem cell-based therapies: autologous transplantation, allogeneic transplantation with human leukocyte antigen-matching and allogeneic transplantation without, and finally the application of "universal" pluripotent stem cells. We also discuss immuno-suppressive treatments and the monitoring of immune reactions in the brain.

Keywords:
Parkinson’s diseaseallogeneicautologoushuman leukocyte antigenimmune response

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