Language Network Connectivity Increases in Early Alzheimer's Disease
Aurélie Pistono1,2, Mehdi Senoussi2, Laura Guerrier3
1Octogone-Lordat Interdisciplinary Research Unit (EA 4156), University of Toulouse II-Jean Jaurès, Toulouse, France.
Journal of Alzheimer'S Disease : JAD
|May 24, 2021
Summary
Early Alzheimer's disease (AD) impacts language. This study found increased functional connectivity in the language network of individuals with mild cognitive impairment (MCI) due to AD, which multivariate analyses could detect.
Area of Science:
- Neuroscience
- Cognitive Science
- Medical Imaging
Background:
- Language production deficits are early indicators of Alzheimer's disease (AD).
- Limited research exists on language network functional connectivity in mild cognitive impairment (MCI) due to AD.
Purpose of the Study:
- To investigate language alterations at the MCI stage, examining both behavioral and neural aspects.
- To utilize univariate and multivariate analyses on structural MRI and resting-state fMRI data.
Main Methods:
- Compared 24 MCI due to AD participants with 24 healthy controls using language evaluations, structural MRI, and resting-state fMRI.
- Performed seed-based analyses on the left inferior frontal and posterior temporal gyri.
- Utilized multivariate pattern analyses to distinguish groups based on network atrophy and functional connectivity patterns.
Main Results:
- MCI due to AD participants exhibited language impairments in tasks and connected speech.
- Multivariate pattern analyses successfully predicted group membership, unlike univariate analyses.
- Language network functional connectivity was a better discriminator than executive control networks, showing increased connectivity correlated with language performance in MCI due to AD.
Conclusions:
- Multivariate analyses are effective for studying neural reorganization in language.
- Increased language network connectivity at the MCI stage may reflect compensatory mechanisms.
Keywords:
Alzheimer’s diseaseconnected speechfunctional MRIfunctional connectivitylanguagemultivariate pattern analysisMore Related Videos
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