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Development of Guidelines for Accurate Measurement of Small Volume Parenteral Products Using Syringes
Melanie A Jordan1, Dimpa Choksi2, Kelsey Lombard3
1Midwestern University, Glendale, AZ, USA.
Hospital Pharmacy
|May 24, 2021
Summary
Accurate measurement of small volumes using syringes in sterile compounding is crucial. Studies show measuring less than 20% of a syringe
Area of Science:
- Pharmaceutical compounding
- Sterile product preparation
- Measurement accuracy
Background:
- Syringes are essential for measuring small volumes in pharmacy compounding, particularly for sterile injectables.
- Current guidelines for accurate small-volume syringe measurement are lacking.
Purpose of the Study:
- To evaluate the accuracy and precision of commercial syringes for small-volume measurements.
- To provide recommendations for optimal syringe selection in sterile compounding.
Main Methods:
- Investigators measured 5%, 10%, or 20% of syringe volumes (1-20 mL) using sterile water.
- Delivered volumes were measured gravimetrically and converted to volume.
- Accuracy and precision were assessed using statistical analysis.
Main Results:
- Syringe accuracy and precision varied significantly, often deviating from theoretical volumes.
- Errors exceeding 5% were more common when measuring less than 20% of a syringe's capacity.
- Mean percent error ranged from 1.4% to 18.6%, highlighting technique's importance.
Conclusions:
- Users should measure at least 20% of a syringe's volume and select the closest possible syringe size.
- Diluting small volumes to match the smallest available syringe size is recommended.
- Proper training and adherence to these guidelines enhance dosing accuracy and patient safety.
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