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Related Experiment Video

Updated: Nov 4, 2025

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection
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Cardiac Structure and Function Is Associated With Hemispatial Neglect Severity.

Nicole L Williams1, Adrian Suarez1, Serban Negoita1

  • 1Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Frontiers in Neurology
|May 24, 2021
PubMed
Summary

Cardiac function, specifically left ventricular and left atrial size, may influence hemispatial neglect severity after right hemispheric stroke. These findings suggest cardiac structure impacts functional outcomes beyond infarct size.

Keywords:
cardiachemispatial neglectleft ventriclerecoverystroke

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Area of Science:

  • Neurology
  • Cardiology
  • Medical Imaging

Background:

  • Hemispatial neglect is a common and disabling outcome of right hemispheric ischemic stroke (RIS).
  • Patient-level factors, including cardiac function, may influence the severity of neglect.
  • Understanding these factors is crucial for predicting and managing functional deficits post-stroke.

Purpose of the Study:

  • To investigate the association between cardiac function and the presence/severity of hemispatial neglect.
  • To determine if this association is independent of infarct size in RIS patients.
  • To explore the role of left ventricular and left atrial structure/function.

Main Methods:

  • Included 218 non-demented RIS patients with cerebral MRI and echocardiography.
  • Assessed neglect using ≥1 of 4 validated tests, categorizing severity.
  • Utilized multivariable and multinomial logistic regression to analyze associations with cardiac parameters.

Main Results:

  • Fifty-eight percent (27%) of patients exhibited neglect.
  • Enlarged left ventricular systolic diameter showed a trend towards increased neglect risk, though not significant after covariate adjustment.
  • Increased left atrial diameter was associated with higher neglect severity, but this finding lost statistical significance in the final model.

Conclusions:

  • Markers of diastolic dysfunction, such as enlarged left ventricle and compensatory left atrial enlargement, were associated with neglect severity.
  • Cardiac structure and function appear to influence not only the infarct volume but also its functional consequences.
  • Further research is warranted to elucidate the mechanisms linking cardiac health and post-stroke neglect.