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Could amantadine interfere with COVID-19 vaccines based on the LNP-mRNA platform?
Jaroslaw J Fedorowski1,2,3,4
1Polish Hospital Federation, Poland.
Introduction:
Amantadine is a well-known medication with indications in neurology and infectious diseases. It is currently FDA approved for Parkinson's disease, drug-induced extrapyramidal symptoms, and influenza.
Methods:
The article is the author's original research hypothesis.
Results:
Because more people are going to be vaccinated and additional similar vaccines are going to be introduced, we should take into consideration the potential of amantadine to interfere with LNP-mRNA COVID-19 vaccine delivery into the target cells.
Conclusions:
A more cautious approach to the patients taking amantadine as far as vaccination utilizing LNP-mRNA platform should be considered.
