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Inflammation can increase hepcidin in HFE-hereditary hemochromatosis

Wenke Moris1,2,3, Pauline L M Verhaegh2,3, Ad A M Masclee2,3

  • 1Department of Internal Medicine, Gastroenterology and Clinical Geriatrics Zuyderland Medical Center Sittard-Geleen The Netherlands.

Clinical Case Reports
|May 24, 2021
PubMed
Summary

This study shows how inflammation can raise hepcidin levels in a patient with a specific HFE gene mutation. This suggests the JAK/STAT3 pathway may override normal iron regulation during illness.

Keywords:
hemochromatosishepcidininflammationiron overload

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