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Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
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miRNA-Based Therapeutics in Breast Cancer: A Systematic Review
Anna Maria Grimaldi1, Marco Salvatore1, Mariarosaria Incoronato1
1IRCCS SDN, Naples, Italy.
Frontiers in Oncology
|May 24, 2021
Summary
MicroRNAs (miRNAs) show promise as novel therapeutics for breast cancer (BC), particularly triple-negative BC. However, current research remains preclinical, highlighting the need for further investigation before clinical application.
Area of Science:
- Oncology
- Molecular Biology
- Biotechnology
Background:
- Breast cancer (BC) is a leading cause of cancer mortality in women globally.
- Therapeutic resistance and tumor relapse limit conventional BC treatments.
- MicroRNA (miRNA)-based therapeutics offer a promising, yet underdeveloped, avenue for BC treatment.
Conclusions:
- miRNAs represent a developing area for BC therapeutic strategies.
- Current research is predominantly preclinical, with limited translatability to clinical practice.
- Further investigation is required to advance miRNA therapeutics for BC treatment.
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