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Case Report: Infective Endocarditis Caused by Aspergillus flavus in a Hemodialysis Patient
Tingting Dai1, Qinghua Hu2, Zhongshang Xie2
1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
Abstract:
Fungal endocarditis (FE) is a rare but fatal disease. The incidence of infective endocarditis (IE) in hemodialysis patients with catheters is thought to be obviously higher than that in the general population. We reported a case of IE caused by Aspergillus flavus (A. flavus) in a 36-year-old woman on hemodialysis. Because the blood cultures were persistently negative, so we used mNGS (Metagenomic next generation sequencing) for early clinical diagnosis. After treatment with voriconazole, the patient's condition improved rapidly. She continued oral voriconazole treatment 1 year after discharge and is in good condition. The diagnosis and treatment strategies of FE in hemodialysis patients were discussed.
Insights
Fungal endocarditis (FE) is a rare, fatal condition. Metagenomic next-generation sequencing (mNGS) aided early diagnosis in a hemodialysis patient with Aspergillus flavus endocarditis, leading to successful voriconazole treatment.
Area of Science:
- Infectious Diseases
- Mycology
- Nephrology
Background:
- Fungal endocarditis (FE) is a rare but severe condition.
- Hemodialysis patients with catheters have an increased risk of infective endocarditis (IE).
- Early diagnosis and effective treatment are crucial for managing FE in this vulnerable population.
