Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inflammation

Inflammation

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Atherosclerosis I: Introduction

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

<i>Fucus vesiculosus</i> fucoidan alone and in combination with simvastatin is associated with both alleviation of atherosclerosis and modulations in the gut microbiota and its metabolites in New Zealand rabbits.

Frontiers in microbiology·2026

Same author

The combination of Fucus vesiculosus-derived fucoidan and simvastatin attenuates atherosclerosis induced by a high-fat diet plus balloon catheter injury in New Zealand rabbits.

International journal of biological macromolecules·2025

Same author

Parotid metastasis of rare lung adenocarcinoma: A case report.

World journal of clinical cases·2024

Same author

Konjac glucomannan promoted fabrication of diacylglycerol oil-based oleogels through emulsion-templated approach: Comparison with triacylglycerol oleogels.

International journal of biological macromolecules·2023

Same author

Current trends of high-risk gene Cul3 in neurodevelopmental disorders.

Frontiers in psychiatry·2023

Same author

Targeted DNA N<sup>6</sup>-methyladenine editing by dCas9 fused to METTL4 in the lepidopteran model insect Bombyx mori.

Insect science·2023

Search research articles

Related Experiment Video

Updated: Nov 4, 2025

An In vitro Model to Study Heterogeneity of Human Macrophage Differentiation and Polarization

An In vitro Model to Study Heterogeneity of Human Macrophage Differentiation and Polarization

Published on: June 12, 2013

Macrophage Plasticity and Atherosclerosis Therapy.

Ping Lin¹, Hong-Hai Ji¹, Yan-Jie Li¹

¹Institute of Lipid Metabolism and Atherosclerosis, Innovative Drug Research Centre, School of Pharmacy, Weifang Medical University, Weifang, China.

Frontiers in Molecular Biosciences

|May 24, 2021

Summary

Atherosclerosis involves diverse macrophage phenotypes within plaques. Targeting these heterogeneous immune cells offers new therapeutic strategies for atherosclerosis regression beyond lipid-lowering treatments.

Keywords:

ER stress apoptosis inflammation lipid metabolism macrophage polarization plaque microenvironment

More Related Videos

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

Related Experiment Videos

Last Updated: Nov 4, 2025

An In vitro Model to Study Heterogeneity of Human Macrophage Differentiation and Polarization

An In vitro Model to Study Heterogeneity of Human Macrophage Differentiation and Polarization

Published on: June 12, 2013

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

Area of Science:

Immunology
Cardiovascular Biology

Background:

Atherosclerosis is a chronic inflammatory disease characterized by monocyte-derived macrophages in plaques.
Macrophage phenotype dictates atherosclerotic plaque size, composition, and stability.
Macrophage heterogeneity and plasticity are critical in plaque progression.

Purpose of the Study:

To review macrophage phenotypic diversity in atherosclerosis.
To elucidate the role of macrophages in dynamic atherosclerotic plaque progression.
To explore therapeutic strategies targeting the macrophage microenvironment for atherosclerosis treatment.

Main Methods:

Literature review focusing on macrophage biology in atherosclerosis.
Analysis of studies investigating microenvironmental regulation of macrophage phenotypes.
Discussion of current therapeutic limitations and future directions.

Main Results:

Macrophage phenotype is modulated by plaque microenvironment factors like lipids and cytokines.
The M1/M2 classification is an oversimplification; macrophages exhibit a spectrum of phenotypes.
Atherosclerotic plaque macrophages display significant heterogeneity and plasticity.

Conclusions:

Understanding macrophage phenotypic diversity is key to deciphering their role in atherosclerosis.
Targeting macrophage heterogeneity and plasticity presents a promising avenue for atherosclerosis regression.
Modulating the macrophage microenvironment may offer novel therapeutic approaches for atherosclerosis.