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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Nov 4, 2025

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
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Cell therapies in the clinic.

Lily Li-Wen Wang1,2,3, Morgan E Janes1,2,3, Ninad Kumbhojkar1,2

  • 1John A. Paulson School of Engineering & Applied Sciences Harvard University Cambridge Massachusetts USA.

Bioengineering & Translational Medicine
|May 24, 2021
PubMed
Summary

Cell therapies, using living cells, offer unique advantages over traditional drugs for treating diseases. This review covers approved cell therapies, ongoing clinical trials, and challenges in their development.

Keywords:
T cellblood cellcellcell therapyclinical translationclinical trialsmicrobesstem cell

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Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Cellular Therapeutics

Background:

  • Cell therapies represent a significant advancement in medicine, offering unique advantages over conventional treatments.
  • Living cells can perform complex biological functions dynamically, expanding therapeutic options.
  • Cell therapies are a rapidly growing area of research and clinical application.

Purpose of the Study:

  • To highlight the diversity and advantages of cell therapies.
  • To review approved cell therapy products and their clinical applications.
  • To analyze current clinical trials and discuss therapeutic applications.

Main Methods:

  • Review of 28 globally approved cell therapy products.
  • Analysis of over 1700 active clinical trials in cell therapy.
  • Critical discussion of biological, manufacturing, and regulatory challenges.

Main Results:

  • Cell therapies are a promising modality with numerous approved products and active clinical investigations.
  • Diverse therapeutic applications are being explored across various diseases.
  • Significant challenges remain in the biological, manufacturing, and regulatory aspects of clinical translation.

Conclusions:

  • Cell therapies offer unique therapeutic potential and are advancing rapidly in clinical settings.
  • Addressing key challenges is crucial for the successful clinical translation of cell therapies.
  • Continued research and development are essential to realize the full potential of cell-based treatments.