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Pulse wave velocity, carotid intima media thickness and flow-mediated dilation in Takayasu arteritis: a systematic

Jun Watanabe1, Yoshitaka Iwazu2, Kazuhiko Kotani1

  • 1Division of Community and Family Medicine, Jichi Medical University, Shimotsuke-city, Japan.

Archives of Medical Sciences. Atherosclerotic Diseases
|May 24, 2021
PubMed

Insights

Pulse wave velocity (PWV), carotid artery intima-media thickness (CIMT), and flow-mediated dilatation (FMD) may help assess cardiovascular risk in Takayasu arteritis (TA) patients. These markers showed significant differences in TA patients compared to controls.

Area of Science:

  • Vascular Medicine
  • Rheumatology
  • Cardiology

Background:

  • Takayasu arteritis (TA) is a chronic vasculitis.
  • TA is associated with increased cardiovascular risk.
  • Standard cardiovascular risk markers like PWV, CIMT, and FMD have not been fully evaluated in TA patients.

Purpose of the Study:

  • To evaluate the utility of pulse wave velocity (PWV), carotid artery intima-media thickness (CIMT), and flow-mediated dilatation (FMD) for assessing cardiovascular risk in Takayasu arteritis (TA) patients.

Main Methods:

  • A systematic review of clinical studies published before 2021 was conducted using PubMed.
  • Studies reporting PWV, CIMT, and FMD levels in TA patients were included.
  • Data from eligible studies were summarized and compared to control groups.

Main Results:

  • Fifteen studies met the eligibility criteria.
  • TA patients exhibited significantly higher PWV and CIMT levels compared to controls.
  • TA patients demonstrated significantly lower FMD levels compared to controls.
  • Disease activity in TA was significantly associated with PWV, CIMT, or FMD levels in some studies.

Conclusions:

  • PWV, CIMT, and FMD measurements show potential utility in evaluating cardiovascular risk in TA patients.
  • Further research is warranted to establish the optimal application of these measurements in TA management.
Abstract

Keywords:
Takayasu diseasecardiovascular diseaseendothelial dysfunctionpulse wave analysisvascular stiffness

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