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Observational Cross-Sectional Study of Inflammatory Markers After Transient Ischemic Attacks, Acute Coronary

Kevin E Boczar1,2, Peter Liu1, Aun Yeong Chong1

  • 1Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

CJC Open
|May 24, 2021
PubMed

Insights

Patients with prediabetes/diabetes and recent cardiovascular events show higher inflammation markers, including interleukin-6. This suggests a greater inflammatory burden in these individuals compared to those without recent events or dysglycemia.

Area of Science:

  • Biomedical Science
  • Cardiovascular Medicine
  • Inflammation Research

Background:

  • Cardiovascular (CV) events are often associated with inflammatory processes.
  • Prediabetes and diabetes mellitus are known risk factors for cardiovascular disease.
  • Assessing inflammatory markers in patients with recent CV events and dysglycemia is crucial for understanding disease mechanisms.

Purpose of the Study:

  • To determine the prevalence of elevated high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in patients experiencing recent cardiovascular events.
  • To compare inflammatory marker levels in patients with recent CV events and prediabetes/diabetes versus those with remote CV events.
  • To investigate the association between prediabetes/diabetes and heightened inflammatory burden following acute cardiovascular events.

Main Methods:

  • Retrospective analysis of patient data including recent and remote cardiovascular events.
  • Measurement of serum levels of high-sensitivity C-reactive protein and interleukin-6.
  • Comparison of inflammatory marker levels between groups stratified by event recency and glycemic status (prediabetes/diabetes).

Main Results:

  • Interleukin-6 levels were significantly higher in patients with prediabetes/diabetes and recent CV events (median, 4.84 pg/mL) compared to patients with remote CV events (median, 2.36 pg/mL).
  • A trend towards elevated high-sensitivity C-reactive protein was observed in patients with acute events and prediabetes/diabetes (P = 0.147).
  • Patients with prediabetes/diabetes and recent CV events exhibited a greater inflammatory burden.

Conclusions:

  • Patients with prediabetes/diabetes experiencing recent cardiovascular events have a significantly elevated inflammatory burden, particularly indicated by higher interleukin-6 levels.
  • These findings support the link between dysglycemia, acute cardiovascular events, and increased systemic inflammation.
  • Further research into managing inflammation in this patient population may be warranted to reduce cardiovascular risk.

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