Chemoproteomics-based target profiling of sinomenine reveals multiple protein regulators of inflammation
Lianguo Chen1, Hong-Jian Wang1, Teng-Fei Ji1
1State Key Laboratory of Bioactive Substances and Functions of Natural Medicines and Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. zhangchongjing@imm.ac.cn jitf@imm.ac.cn.
Abstract:
Although sinomenine (SIN) has been used to treat several inflammation-related diseases in the clinic for decades, the detailed anti-inflammatory mechanism remains elusive. Here, we present a chemoproteomic study that supports a polypharmacological mode of action for SIN to inhibit inflammation. Notably, functional validation revealed multiple new protein regulators whose knockdown could significantly affect inflammation.
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