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Published on: May 21, 2019
Visible light-induced mono-bromination of arenes with BrCCl3
Jiali Fan1, Qiancheng Wei1, Ershu Zhu1
1Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University (Nanjing Tech), Nanjing 211816, P. R. China. ias_xmcheng@njtech.edu.cn ias_ynlu@njtech.edu.cn teckpeng@ntu.edu.sg.
Abstract:
A highly efficient and regioselective bromination of electron-rich arenes and heteroarenes using commercially available BrCCl3 as a "Br" source has been developed. The reaction was performed in air under mild conditions with photocatalyst Ru(bpy)3Cl2·6H2O, avoiding the usage of strong acids and strong oxidants. Mono-brominated products were obtained with medium to excellent yields (up to 94%). This strategy has shown good compatibility and high para-selectivity, which will facilitate the complicated synthesis.
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