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CD93 has a crucial role in pathogenesis of psoriasis

Wafaa Ahmed Shehata1, Alaa Hassan Maraee1, Nermin Tayel2

  • 1Department of Dermatology, Andrology and STDs, Faculty of Medicine- Menoufia University, Shebin El-Kom, Egypt.

Journal of Cosmetic Dermatology
|May 24, 2021
PubMed

Insights

Cluster of differentiation 93 (CD93) is significantly expressed in psoriatic skin, indicating its role in disease pathogenesis. This finding suggests CD93 as a potential therapeutic target for psoriasis.

Area of Science:

  • Dermatology and immunology
  • Molecular biology and genetics

Background:

  • Psoriasis is a chronic inflammatory skin condition characterized by epidermal proliferation and angiogenesis.
  • Cluster of differentiation 93 (CD93) is an angiogenic factor involved in cell adhesion and inflammation.

Purpose of the Study:

  • To investigate the immunohistochemical expression of CD93 in psoriatic skin.
  • To examine the association between CD93 single nucleotide polymorphisms (SNPs) rs2749817 and psoriasis pathogenesis and severity.

Main Methods:

  • A case-control study involving 50 psoriasis vulgaris patients and 50 healthy controls.
  • Immunohistochemical staining of skin biopsies to assess CD93 expression.
  • Real-time PCR (TaqMan assay) to analyze CD93 rs2749817 gene polymorphism.

Main Results:

  • CD93 expression was significantly higher in dermal endothelial and inflammatory cells of psoriatic skin compared to controls.
  • Stronger CD93 intensity and higher positive cell percentages were observed in psoriasis patients.
  • The TC genotype of CD93 rs2749817 was less frequent in patients, while the CC genotype was exclusively found in cases.

Conclusions:

  • Cluster of differentiation 93 (CD93) plays a significant role in the pathogenesis of psoriasis.
  • CD93 represents a promising therapeutic target for managing psoriasis.
Abstract

Keywords:
CD93angiogenesispsoriasis

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