Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of long-term aerobic exercise on prostate cancer-induced adipose tissue wasting: Browning to the rescue?

Cellular signalling·2026
Same author

Discovery of bridged melanostatin derivatives as potent allosteric modulators of the dopamine D<sub>2</sub> receptors with improved permeability.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Coffee By-Products: An Overview of Their Antimicrobial Properties.

Molecules (Basel, Switzerland)·2026
Same author

Exploring the effects of lifelong aerobic exercise on early skeletal muscle remodeling between 8 and 14 months in the rat.

Journal of physiology and biochemistry·2026
Same author

Are all nanoplastics equally neurotoxic? Influence of size and surface functionalization on the toxicity of polystyrene nanoplastics in human neuronal cells.

Environmental pollution (Barking, Essex : 1987)·2025
Same author

Nutraceutical Profile Characterization in Apricot (<i>Prunus armeniaca</i> L.) Fruits.

Plants (Basel, Switzerland)·2025

Related Experiment Video

Updated: Nov 4, 2025

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

1.1K

Splenic morphologic changes induced by a strenuous and exhaustive training program in Wistar rats.

Sara Maia1, Beshoy Girgis2, Grace F Nunes2

  • 1CIAFEL, Laboratory of Biochemistry and Experimental Morphology, Faculty of Sport, University of Porto, Porto, Portugal - sarahnobre96@hotmail.com.

The Journal of Sports Medicine and Physical Fitness
|May 24, 2021
PubMed
Summary

Intense exercise alters spleen structure and immune cell balance in rats, even without causing overtraining syndrome (OTS). Strenuous training impacts splenic white pulp and T cell populations, suggesting potential immune system compromise.

More Related Videos

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models
08:31

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models

Published on: December 17, 2021

2.9K
Author Spotlight: Investigating the Underlying Mechanisms of Right Ventricular Failure in Pulmonary Hypertension
04:49

Author Spotlight: Investigating the Underlying Mechanisms of Right Ventricular Failure in Pulmonary Hypertension

Published on: June 14, 2024

947

Related Experiment Videos

Last Updated: Nov 4, 2025

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

1.1K
Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models
08:31

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models

Published on: December 17, 2021

2.9K
Author Spotlight: Investigating the Underlying Mechanisms of Right Ventricular Failure in Pulmonary Hypertension
04:49

Author Spotlight: Investigating the Underlying Mechanisms of Right Ventricular Failure in Pulmonary Hypertension

Published on: June 14, 2024

947

Area of Science:

  • Exercise physiology
  • Immunology
  • Histology

Background:

  • Intense physical training can impair immune function and lead to overtraining syndrome (OTS).
  • Understanding the effects of demanding training on immune system structures is crucial.

Purpose of the Study:

  • To investigate splenic morphological and immunological changes in Wistar rats subjected to strenuous exercise.

Main Methods:

  • Rats were divided into control and exercise groups, with exercise lasting 1 or 3 weeks.
  • Animals underwent treadmill training (1 hour/day, 6 days/week) with progressive intensity.
  • Spleens were analyzed histologically and for CD4+, CD8+ T cells, and NF-κB expression.

Main Results:

  • Overtraining syndrome (OTS) was not induced, but splenic white pulp areas decreased after 3 weeks of training.
  • Training led to a reduction in CD4+ T cells and an increase in CD8+ T cells in the spleen.
  • NF-κB P65 expression was elevated in the exercise group compared to controls.

Conclusions:

  • Strenuous physical training alters spleen histology and immune cell composition.
  • These changes suggest a potential compromise in immune system functionality, even in the absence of overt OTS symptoms.