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Related Experiment Video

Updated: Nov 4, 2025

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EUS-guided hydrogel microparticle injection in a cadaveric model.

Seong-Hun Kim1, Kai Ding2, Avani Rao3

  • 1Department of Internal Medicine, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju-si, Jeollabuk-do, Republic of Korea.

Journal of Applied Clinical Medical Physics
|May 24, 2021
PubMed
Summary
This summary is machine-generated.

Endoscopic ultrasound-guided hydrogel injection successfully created space between the pancreas and duodenum in a cadaver model. This technique, using polyethylene glycol (PEG) hydrogel, shows promise for reducing gastrointestinal toxicity in pancreatic cancer radiotherapy.

Keywords:
endosonographyhydrogelpancreatic neoplasmsradiationstereotactic body radiotherapy

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Area of Science:

  • Gastroenterology
  • Radiation Oncology
  • Medical Imaging

Background:

  • Pancreatic head cancer (PHC) treatment, particularly radiotherapy, faces challenges with gastrointestinal (GI) toxicity.
  • Reducing GI toxicity may be achieved by increasing the space between the head of the pancreas (HOP) and the duodenum.
  • Endoscopic ultrasound (EUS)-guided hydrogel injection is an emerging technique to create this peri-pancreatic space.

Purpose of the Study:

  • To evaluate the technical feasibility of EUS-guided hydrogel injection.
  • To assess the creation of space at the peri-pancreatic interface in a cadaveric model.
  • To determine the efficacy of hydrogel for separating the HOP and duodenum.

Main Methods:

  • Three unfixed cadaveric specimens underwent baseline abdominal CT scans.
  • Transduodenal EUS-guided hydrogel injection into the HOP-duodenum interface was performed using a 19G needle.
  • Post-procedure CT imaging and gross dissection confirmed hydrogel localization and measured the created space.

Main Results:

  • Successful EUS-guided hydrogel injection was achieved in all cadavers.
  • Hydrogel volumes of 9.5, 27, and 10 cc created maximum peri-pancreatic spaces of 11.77, 13.20, and 12.89 mm, respectively.
  • Hydrogel was clearly visualized on EUS and CT as hyperechoic bullae without artifacts.

Conclusions:

  • EUS-guided hydrogel delivery is a feasible method for increasing peri-pancreatic space.
  • Polyethylene glycol (PEG) hydrogel is visible on EUS and CT without significant artifacts.
  • This technique offers potential for novel treatment approaches in pancreatic cancer.