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Updated: Nov 4, 2025
Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line
Published on: August 2, 2021
Photobiomodulation induces murine macrophages polarization toward M2 phenotype
Valdison P Reis1, Mauro V Paloschi1, Cristina M A Rego1
1Lab. Imunologia Cellular Aplicada à Saúde, FIOCRUZ-Rondônia, Porto Velho, RO, Brazil.
Abstract:
Photobiomodulation using light-emitting diode (LED) treatment has analgesic and anti-inflammatory effects which can be an effective therapeutic associated with serum therapy for local treatment of snakebites. Here we explored the effects of LED treatment on isolated macrophage under Bothrops jararacussu venom. Results showed that LED induced IL-6 and TNF-α genes down-regulation and, TGF and ARG1 genes up-regulation which indicates a polarization of macrophages to an M2 phenotype contributing to both tissue repair and resolution of inflammation.
