Microphysiological models of the central nervous system with fluid flow

Area of Science:

• Neuroscience
• Biomedical Engineering
• Pathology

Background:

• Over 1,000 neurological and neurodegenerative disorders affect 100 million Americans, costing $800 billion annually.
• Current model systems are insufficient for studying the complex mechanisms and treatments of these conditions.
• Neuropathology impacts central nervous system (CNS) fluid flow, affecting conditions from injury to aging.

Purpose of the Study:

• To review advances in 3D microphysiological systems for CNS disorder research.
• To highlight the importance of incorporating biological fluid flow into neural models.
• To explore the potential of these systems for studying neuropathology and developing therapies.

Main Methods:

• Review of recent literature on 3D microphysiological systems.
• Focus on systems capable of simulating biological fluid flow.
• Analysis of how fluid dynamics relate to CNS physiology and pathology.

Main Results:

• Microphysiological systems offer a promising platform for modeling neural tissues.
• Incorporating biophysical forces, like fluid flow, enhances model realism.
• Altered fluid flow is a common factor in various CNS pathologies.

Conclusions:

• 3D microphysiological systems are valuable tools for understanding CNS disorders.
• Integrating biological fluid flow is essential for accurate modeling of neural diseases.
• These advanced models can accelerate the development of novel therapeutic strategies.