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Updated: Nov 4, 2025
Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment
Published on: September 7, 2022
Role of epigallocatechin gallate in collagen hydrogels modification based on physicochemical characterization and
Xiaoyue Yu1, Jinling Li1, Mingtao Yang2
1College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China; The Sub Center (Wuhan) of National Technology and R&D of Staple Freshwater Fish Processing, Wuhan 430070, PR China.
Abstract:
Collagen Type I derived from fish is mainly limited by its poor physicochemical properties for further applications. In this study, we developed epigallocatechin gallate (EGCG) cross-linked collagen hydrogels (EC hydrogels) to realize physicochemical improvements, basing on the interaction mechanism between collagen and EGCG. The integrity of collagen framework with slight secondary structure change in the presence of EGCG was confirmed. The stronger stability of collagen fibrils was proved by slower swelling ratio, declined enzymatic degradation, improved thermal analysis and mechanical test due to EGCG modification. To illustrate the potential mechanism between collagen and EGCG, molecular docking was used to identify both covalent (CN bond, between lysine of collagen and C2-ring B of EGCG) and non-covalent bonds (hydrogen bond and hydrophobic interaction) within in EC hydrogel. Taken together, this work would offer some insights into the further study about the interaction between EGCG and collagen.
