Case report: asenapine and anticholinergic toxicity.
Ann Kathleen Sheehan1,2, Christopher Richards-Bentley1,3, Raed J Hawa1,2
1Department of Psychiatry, University of Toronto.
International Clinical Psychopharmacology
|May 24, 2021
Summary
Asenapine, an antipsychotic, may cause anticholinergic toxidrome despite prior in vitro studies. This case highlights the need to consider asenapine
Area of Science:
- Neuropharmacology
- Clinical Toxicology
Background:
- Antipsychotic medications are frequently associated with anticholinergic effects.
- Asenapine was previously thought to lack muscarinic cholinergic antagonism based on in vitro data.
- In vitro findings contrast with in vivo rat brain studies showing greater cholinergic binding for asenapine.
More Related Videos
08:16Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity
Published on: September 21, 2021
3.6K
08:23Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain
Published on: May 12, 2018
9.7K