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Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Updated: Nov 4, 2025

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Published on: February 14, 2022

Pushing the Envelope for Donor Lungs.

Etienne Abdelnour-Berchtold¹, Aadil Ali¹, Marcelo Cypel¹

¹The Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Seminars in Respiratory and Critical Care Medicine

|May 24, 2021

Summary

This summary is machine-generated.

Lung transplantation faces donor shortages and low organ utilization. This review explores strategies to expand the donor pool and improve lung quality, aiming for better transplant outcomes.

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Orthotopic Left Lung Transplantation in Rats

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Last Updated: Nov 4, 2025

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

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Published on: February 14, 2022

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

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Orthotopic Left Lung Transplantation in Rats

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Area of Science:

Transplantation immunology
Organ preservation
Donor management

Background:

Lung transplant waiting lists exceed donor availability.
Low utilization rates of available donor lungs persist.
Donor lung quality is often suboptimal due to age, smoking, or size mismatch.

Purpose of the Study:

To review strategies for increasing the donor lung pool.
To challenge traditional limitations for organ utilization.
To present advances in donor management, ex vivo lung assessment, and preservation.

Main Methods:

Review of current literature on donor lung optimization.
Analysis of novel donor management strategies.
Examination of ex vivo lung assessment and preservation techniques.

Main Results:

Challenging donor acceptance criteria can increase lung availability.
Ex vivo platforms offer new avenues for lung assessment and therapy.
Improvements in lung preservation enhance allograft quality.

Conclusions:

Donor lung optimization is a comprehensive strategy to increase allograft numbers and quality.
These strategies aim to improve transplant outcomes without compromising patient safety.
Future research focuses on expanding the donor pool and refining organ preservation.