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Updated: Nov 4, 2025
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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
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Effectual nanotherapy against oral squamous cell carcinoma
Rituraj Bharadwaj1, Subhash Medhi1
1Department of Bioengineering and Technology, Laboratory of Molecular Virology and Oncology, Gauhati University, Guwahati, India.
Drug Development and Industrial Pharmacy
|May 25, 2021
Summary
Folic acid (FA) conjugated solid lipid nanoparticles (SLN) loaded with paclitaxel and ascorbic acid show enhanced efficacy for oral squamous cell carcinoma (OSCC) treatment in preclinical models.
Area of Science:
- Nanotechnology in drug delivery
- Cancer therapeutics
- Oral squamous cell carcinoma research
Background:
- Oral squamous cell carcinoma (OSCC) is a prevalent and deadly cancer.
- Novel drug delivery systems are needed to improve OSCC treatment outcomes.
Purpose of the Study:
- To develop and evaluate folic acid (FA) conjugated solid lipid nanoparticles (SLN) loaded with paclitaxel (PTX) and ascorbic acid (AA) for OSCC treatment.
- To assess the efficacy of FA-conjugated SLN in combination therapy.
Main Methods:
- FA-conjugated SLN were prepared using high-speed homogenization and ultrasonication.
- Efficacy was evaluated in an OSCC-induced animal model.
- Pharmacokinetic and biodistribution studies were conducted.
Main Results:
- FA-conjugated SLN exhibited biphasic drug release both in vitro and in vivo.
- Combination therapy with FA-conjugated PTX-SLN and FA-conjugated AA-SLN demonstrated superior efficacy compared to individual treatments.
- Pharmacokinetic and biodistribution studies indicated better therapeutic efficacy for FA-conjugated SLN over conventional drugs.
Conclusions:
- FA-conjugated SLN show significant potential for effective OSCC treatment.
- The developed nanocarrier system offers a promising approach for managing oral squamous cell carcinoma.
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