Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

269
Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
269
Human Genetics01:28

Human Genetics

959
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
959
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

715
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
715
Genetic Lingo01:11

Genetic Lingo

108.8K
Overview
108.8K
Personality Disorders: Dependent and Obsessive-Compulsive01:24

Personality Disorders: Dependent and Obsessive-Compulsive

184
Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle...
184
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

218
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
218

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trajectory of irritability in children and youth in Ontario, Canada, throughout the COVID-19 pandemic.

JCPP advances·2026
Same author

Identification of moderate effect size genes in autism spectrum disorder through a novel gene pairing approach.

Communications biology·2026
Same author

Genetic architecture of postpartum psychosis: from common to rare genetic variation.

Molecular psychiatry·2026
Same author

Deleterious coding variation associated with autism is shared across ancestries.

Nature medicine·2026
Same author

Sibling Psychiatric Disorders and Risk of Postpartum Psychosis.

medRxiv : the preprint server for health sciences·2025
Same author

Working memory load-dependent modulation of neural activity predicts response to cognitive behavioral therapy in obsessive-compulsive disorder.

Translational psychiatry·2025

Related Experiment Video

Updated: Nov 4, 2025

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

15.7K

Genetics of obsessive-compulsive disorder.

Behrang Mahjani1,2,3,4, Katharina Bey5, Julia Boberg6

  • 1Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Psychological Medicine
|May 25, 2021
PubMed
Summary

Genetics plays a significant role in obsessive-compulsive disorder (OCD), a heritable condition influenced by common and rare genetic variants. Future research will explore gene-environment interactions and epigenetic factors in OCD.

Keywords:
Obsessive-compulsive disordergenetic epidemiologymolecular geneticsobsessive-compulsive symptoms

More Related Videos

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

521
Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
06:50

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

Published on: December 24, 2013

29.2K

Related Experiment Videos

Last Updated: Nov 4, 2025

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

15.7K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

521
Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
06:50

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

Published on: December 24, 2013

29.2K

Area of Science:

  • Psychiatry
  • Genetics
  • Epidemiology

Background:

  • Obsessive-compulsive disorder (OCD) is a complex psychiatric condition.
  • OCD exhibits familial clustering, indicating a substantial genetic influence on its development.
  • Genetic factors are crucial in understanding the etiology of OCD.

Purpose of the Study:

  • To review the current understanding of genetic epidemiology in OCD.
  • To summarize findings from molecular genetic studies on OCD and related symptoms.

Main Methods:

  • Review of existing genetic epidemiology studies.
  • Analysis of molecular genetic research on OCD.
  • Examination of twin and genome-wide association studies.

Main Results:

  • OCD is a polygenic disorder with both common and rare genetic variants contributing to risk.
  • Significant additive genetic contributions to OCD liability have been identified.
  • OCD shares genetic risks with comorbid conditions like Tourette syndrome and anorexia nervosa.

Conclusions:

  • The precise mechanisms linking genetic and environmental factors in OCD remain largely unknown.
  • Future research should focus on increasing genetic diversity, exploring age/sex differences, and investigating gene-environment interactions and epigenetics in OCD.