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Updated: Nov 4, 2025

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

Necrotizing Enterocolitis.

Jennifer Duchon¹, Maria E Barbian², Patricia W Denning³

¹Division of Newborn Medicine, Jack and Lucy Department of Pediatrics, Icahn School of Medicine at Mount Sinai, 1000 10th Avenue, New York, NY 10019, USA.

Clinics in Perinatology

|May 25, 2021

Summary

Necrotizing enterocolitis (NEC) is an inflammatory disease in premature infants. This review explores how gut bacteria influence NEC risk and discusses optimizing probiotic and antibiotic therapies for prevention and treatment.

Keywords:

Antibiotic use in newborns Intestinal immaturity Intestinal inflammation NEC Necrotizing enterocolitis Prematurity Probiotics

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Last Updated: Nov 4, 2025

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Published on: June 8, 2022

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

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Published on: April 10, 2019

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

Area of Science:

Neonatal Medicine
Microbiology
Gastroenterology

Background:

Necrotizing enterocolitis (NEC) is a severe inflammatory condition primarily affecting premature infants.
Intestinal microbial dysbiosis is increasingly recognized as a significant factor in NEC development and severity.
Optimal antibiotic and probiotic strategies for NEC prevention and treatment remain unclear.

Purpose of the Study:

To review the role of intestinal microbial composition in NEC pathogenesis.
To discuss risk factors associated with NEC in preterm infants.
To explore the potential of probiotic and antibiotic therapies in managing NEC.

Main Methods:

Literature review of studies on NEC, microbial composition, and therapeutic interventions.
Analysis of the impact of dysbiosis on NEC pathogenesis.
Discussion of current and emerging treatment strategies.

Main Results:

Preterm infant gut microbiota composition is a critical determinant of NEC predisposition and risk.
Dysbiosis plays a central role in the inflammatory processes leading to NEC.
Evidence suggests potential benefits of targeted probiotic and antibiotic therapies.

Conclusions:

Modulating the intestinal microbiome holds promise for NEC prevention and treatment.
Further research is needed to optimize antibiotic regimens and probiotic use in neonates.
Understanding microbial-host interactions is key to improving outcomes for premature infants with NEC.