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The pharmacokinetic profile of naproxen suppository in man
P J Guelen1, T J Janssen, M M Brueren
1Farma Research B. V., Ravenstein, The Netherlands.
International Journal of Clinical Pharmacology, Therapy, and Toxicology
|April 1, 1988
Abstract:
After a rectal dose of 500 mg in a suppository, naproxen is 6-O-demethylated (20%) and glucuronidated (40%), the metabolites are subsequently excreted renally. The elimination half-life is 15.2 +/- 2.6 h. Ten out of 22 subjects show biphasic elimination kinetics with half-lives of 7 and 15 h, respectively. There is a wide range in the percentage of the dose that is glucuronidated and demethylated (20-70%). This variation does not deviate from a normal distribution.