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Updated: Nov 4, 2025

Isolation and Physiological Analysis of Mouse Cardiomyocytes
Published on: September 7, 2014
Nonischemic cardiomyopathy with reduced ejection fraction secondary to hyperthyroidism
Melanie M Martin1, Megan R Collins
1Melanie M. Martin and Megan R. Collins practice at Dickinson Regional Heart Care Clinic in Iron Mountain, Mich. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Dilated cardiomyopathy, a form of heart failure, can stem from various causes. This case highlights hyperthyroidism as a reversible cause of new-onset heart failure mimicking idiopathic dilated cardiomyopathy.
Area of Science:
- Cardiology
- Endocrinology
- Internal Medicine
Background:
- Dilated cardiomyopathy (DCM) is characterized by left ventricular dilation and impaired systolic function, often presenting as heart failure.
- Etiologies of DCM are diverse, including ischemic, hypertensive, valvular, endocrine, substance-induced, and viral causes.
Observation:
- A patient presented with new-onset heart failure and was initially diagnosed with idiopathic dilated cardiomyopathy and viral pericarditis.
- Further investigation revealed the underlying cause to be hyperthyroidism.
Findings:
- Hyperthyroidism can present with cardiac manifestations mimicking idiopathic dilated cardiomyopathy.
- Prompt diagnosis and management of hyperthyroidism led to resolution of heart failure symptoms.
Implications:
- This case underscores the importance of considering and screening for endocrine disorders, particularly hyperthyroidism, in patients with new-onset heart failure of unclear etiology.
- Recognizing and treating hyperthyroidism can reverse cardiac dysfunction, preventing progression to end-stage heart failure.
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Myocarditis III: Medical Management

