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Amelioration of inflammation in young men with cardiovascular risks participating pedometer-based walking programme

N O Omar1, R A Ahmad2, M S Mohd Shah3

  • 1Universiti Sains Malaysia, School of Medical Sciences, Department of Physiology, Kubang Kerian, Kelantan, Malaysia. suhanakk@usm.my.

The Medical Journal of Malaysia
|May 25, 2021
PubMed

Insights

A pedometer-based walking program significantly reduced inflammation markers like CRP, IL-6, and TNF-α in sedentary young Malaysian men. This intervention improved cardiovascular health by increasing daily steps and reducing inflammatory markers.

Area of Science:

  • Cardiovascular Health
  • Exercise Physiology
  • Inflammation Biomarkers

Background:

  • Cardiovascular disease (CVD) is a growing concern among young Malaysian men, linked to sedentary lifestyles.
  • Inflammation is a key factor in the development of cardiovascular events.
  • Lack of physical activity exacerbates CVD risk factors.

Purpose of the Study:

  • To evaluate the impact of a pedometer-based walking program on reducing inflammation in sedentary young men.
  • To measure changes in C-Reactive protein (CRP), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-α).

Main Methods:

  • 70 sedentary young men (20-40 years) with cardiovascular risk factors were recruited.
  • Participants were randomized into a control group (CG) and a pedometer group (PG) aiming for 8,000 steps/day.
  • Inflammatory markers, anthropometric variables, and lipids were measured at baseline, 6, and 12 weeks.

Main Results:

  • The PG significantly increased daily step count (p<0.001) and improved anthropometric and lipid profiles (p<0.001).
  • Significant reductions in CRP, IL-6, and TNF-α were observed in the PG (p<0.001).
  • No significant changes were noted in the control group.

Conclusions:

  • Pedometer-assisted walking programs are effective in reducing inflammation in young sedentary men.
  • This intervention improves key health indicators related to cardiovascular disease risk.
  • Increased physical activity, even at moderate levels, positively impacts inflammatory markers.
Abstract

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