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Updated: Nov 4, 2025

Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
Intestinal adaptation in fluid restricted cardiac failure following extensive bowel resection
M Jothinathan1, Y Y Gan2, A Qayyum3
1Sarawak General Hospital, Department of Surgery, Sarawak, Malaysia. jothinathan84@gmail.com.
Acute mesenteric ischemia (AMI) requires prompt intervention. This case highlights successful damage control surgery and anastomosis in a patient with cardiac failure, avoiding short bowel syndrome.
Area of Science:
- Gastroenterology
- Surgical Innovation
- Critical Care Medicine
Background:
- Acute mesenteric ischemia (AMI) is a critical surgical emergency with high mortality.
- Early diagnosis and intervention are crucial for patient outcomes.
- Damage control surgery is recommended for critically ill patients with AMI.
Observation:
- A 56-year-old female with decompensated cardiac failure presented with severe epigastric pain and distension.
- She had extensive bowel ischemia involving the superior mesenteric artery distribution.
- Damage control surgery followed by entero-colic anastomosis was performed.
Findings:
- The patient recovered well with remarkable intestinal adaptation.
- She did not exhibit symptoms of short bowel syndrome.
- This occurred despite the theoretical risk of altered intestinal permeability in cardiac failure.
Implications:
- Damage control surgery can be effective in managing extensive AMI, even in patients with comorbidities.
- Intestinal adaptation is possible, mitigating the risk of short bowel syndrome.
- This case challenges assumptions about intestinal adaptation in the context of cardiac decompensation.
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